Document Details

Document Type : Article In Journal 
Document Title :
Cytotoxic and protective DNA damage of three new diterpenoids from the brown alga Dictoyota dichotoma
Cytotoxic and protective DNA damage of three new diterpenoids from the brown alga Dictoyota dichotoma
 
Subject : Chemistry 
Document Language : English 
Abstract : Three new diterpenes Amijiol acetate (3), dolabellane, Dolabellatrienol (4), and dolastane, Amijiol-7, 10-diacetate (9) were isolated together with the previously described Pachydictyol A (1), Isopachydictyol A (2), 8β-hydroxypachydictyol A (5), Amijiol (6), Isodictyohemiacetal (7) and Dictyol C (8) from the Red Sea brown alga Dictyota dichotoma var. implexa. The structures and relative stereochemistry of the new diterpenoids were proposed on the basis of their spectral data. Compounds 3 and 9 have potent activity against DNA damage, cytotoxicity against WI-38, HepG2, and MCF-7 cell lines, and antioxidant using ABTS and erythrocytes hemolysis. 
ISSN : 0223-5234 
Journal Name : European Journal of Medicinal Chemistry 
Volume : 46 
Issue Number : 1 
Publishing Year : 1432 AH
2011 AD
 
Article Type : Article 
Added Date : Saturday, March 3, 2012 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
سيف الدين نصر عيادAyyad, Seif-Eldin NResearcherDoctoratesnayyad2@yahoo.com
محمد صالح إبراهيم توفيق مكيMakki, Mohamed S. I. TResearcherDoctoratemmakki@kau.edu.sa
نزيهه سليمان الكيالAl-Kayal, Nazeeha SResearcherMasternalkayal@yahoo.com
سالم أحمد باسيفBasief, Salem AResearcherDoctoratesbasaif@yahoo.com
خالد عمر الفوتيAl-Footy, Khalid OmarResearcherDoctoratekalfooti@kau.edu.sa
عبدالله محمد عسيريAsiri, Abdullah MohamedResearcherDoctorateaasiri2@kau.edu.sa
وليد محمد العارفAlarif, Walied MohamedResearcherDoctoratewelaref@kau.edu.sa
Farid Abd Al Raheem BadriaBadria, Farid Abd Al RaheemResearcherDoctorate 

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