Document Details

Document Type : Thesis 
Document Title :
EXPERIMENTAL STUDIES TO EVALUATE NON-INVASIVE OSTEOINDUCIVE METHODS FOR THE REPAIR OF SURGICALLY PREPARED MAXILLARY ALVEOLAR CLEFT IN RABBITS
دراسة تجريبية لتقييم طرق جديدة غير إجتياحية باستخدام أدوية تنشط بناء العظام في إلتئام شقوق الفك العلوي السنخية المفتعلة جراحياً في الأرانب
 
Subject : Faculty of Dentistry 
Document Language : Arabic 
Abstract : The aim: To assess the effect of recombinant human bone morphogenetic protein-2 (BMP-2) with different concentration of poly lactide-co-glycolide (PLGA), ploycaprolacton (PCL) and PLGA type on bone regeneration in closed bony defects in rabbits using histology and Micro CT images. Materials and Methods: Sixty, 5 weeks old, New Zealand rabbits used in this study, divided randomly into 3 groups A, B and C according to the formula assigned formula A (PLGA 30%, PCL 15%, PLGA type 75:25), formula B (PLGA 10%, PCL 5%, PLGA type 75:25) and formula C (rhBMP-2 in normal saline). Result: Group A showed the highest amount of bone formation 85.16% and complete healing of the defect wall than group B 48.14% and C 19.47%. These results were confirmed by micro-CT findings in which group A showed the highest new bone formation and complete healing of the defect wall when compared to group B (partial healing of the defect wall and less bone formation) and group C ( incomplete healing of the defect wall and lowest new bone formation). Conclusion: Optimum bone formation was achieved using formula A which had lower initial burst and prolonged drug sustained in the defect site 78%. 
Supervisor : Dr. Ali Habibullah Akbar Ali Hassan 
Thesis Type : Master Thesis 
Publishing Year : 1439 AH
2018 AD 
Added Date : Monday, January 8, 2018 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
رياض علي آل مقبولAl Maqbool, Riad AliResearcherMaster 

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