Document Details

Document Type : Thesis 
Document Title :
THE ASSOCIATION BETWEEN ABO/RH/KELL BLOOD GROUPS PHENOTYPES AND DUFFY BLOOD GROUP GENOTYPE WITH ACUTE LEUKAEMIA
العلاقة بين النمط الظاهري لفصائل الدم من نوع ABO/RH/Kell بالاضافة للنمط الجيني لفصيلة دم Duffy مع مرض اللوكيميا الحادة
 
Subject : faculty of Applied Medical Sciences 
Document Language : Arabic 
Abstract : Introduction: Leukaemia considers the 6th type of cancer that causes death in Saudi Arabia. Different studies have linked different epidemiological factors to leukaemia like age. However, there are few studies that investigated the association between blood groups and leukaemia. Objective: Determine any significant relation between ABO/Rh/Kell blood groups and acute leukaemia, in addition to specify if there are any SNPs from Duffy blood group that can be considered as a risk factor for acute leukaemia. Methods: The retrospective study for ABO/RhD phenotypes done by collecting demographic data and blood group types from KAUH Phoenix software for the period from 2010 till 2019. The prospective case control study done on samples that have been collected from 80 ALL and 20 AML patients and 100 controls to perform serology test by gel card for RhCE/K phenotypes in addition to perform SSP-PCR using four Fy alleles for Duffy genotypes. Results and Discussion: Data from 320 ALL and 144 AML patients were collected. A chi-square test was performed to examine the association between ABO/Rh/Kell phenotypes and Duffy genotypes with acute leukaemia, no significant association was found with ABO/RhD phenotypes. While the association between RhCE/K phenotypes with acute leukaemia (p =0.014) and ALL (p =0.019) were significant, where phenotype cceeK- (C-E-c+e+K-) was significantly higher in patients. There was a significant association between null Fy genotypes with acute leukaemia and ALL (p =0.03), where FY*AES/FY*BES genotype was significantly lower in patients than control subjects. For FY*A allele analysis, ALL compared with AML showed a significant association (p =0.04) where people who are FY*A positive are more likely to have ALL than AML. FY*AES allele analysis showed significant association between control samples and acute leukaemia and control vs ALL (p =0.01), samples from FY*AES allele negative patient were more likely to be affected with acute leukaemia or ALL. Conclusion: RhCE/K phenotypes and Duffy genotypes might be used as a promising marker to predict acute leukaemia high risk group from early stage and follow up until they pass the risk age. 
Supervisor : Dr. Mohamad Yassin Saka 
Thesis Type : Master Thesis 
Publishing Year : 1441 AH
2020 AD 
Co-Supervisor : Dr. Waleed Bawazir 
Added Date : Thursday, February 6, 2020 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
شهد حامد الجهنيAljuhani, Shahad HamedResearcherMaster 

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